Payload Information
General Information of This Payload
| Payload ID | PAY0BWJOR |
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|---|---|---|---|---|---|---|
| Name | CL202203715A1 Vb |
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| Synonyms |
CL202203715A1 Vb
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| Structure |
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| Formula | C43H65N5O9S |
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| Isosmiles | CCCCCON(C(/C(NC([C@@H]1N(CCCC1)C)=O)=C(CC)/C)=O)[C@@H](C(C)C)C[C@@H](OC(C)=O)C2=NC(C(N[C@@H](CC3=CC=C(O)C=C3)CC(C)(C)C(O)=O)=O)=CS2 |
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| InChI |
InChI=1S/C43H65N5O9S/c1-10-12-15-22-56-48(41(53)37(28(5)11-2)46-39(52)34-16-13-14-21-47(34)9)35(27(3)4)24-36(57-29(6)49)40-45-33(26-58-40)38(51)44-31(25-43(7,8)42(54)55)23-30-17-19-32(50)20-18-30/h17-20,26-27,31,34-36,50H,10-16,21-25H2,1-9H3,(H,44,51)(H,46,52)(H,54,55)/t31-,34+,35+,36+/m0/s1
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| InChIKey |
ISCXONKHYNCCRB-KHCOHBKDSA-N
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| Pharmaceutical Properties | Molecule Weight |
828.086 |
Polar area |
187.7 |
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Complexity |
1657.955968 |
xlogp Value |
6.9445 |
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Heavy Count |
58 |
Rot Bonds |
22 |
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Hbond acc |
11 |
Hbond Donor |
4 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
TRSQ-ZP3A- LP24-Vb [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.04 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 44% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
TRSQ-ZP3A- LP6-Vb [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.046 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 43% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
TRSQ-ZP3A- LP23-Vb [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.063 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 45% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||