Payload Information
General Information of This Payload
Payload ID | PAY0BCUKO |
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Name | GRM cpd 18 |
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Synonyms |
GRM cpd 18
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Target(s) | Glucocorticoid receptor (NR3C1) | |||||
Structure | ||||||
Formula | C34H37NO6 |
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Isosmiles | CC12C=CC(=O)C=C1CCC1C3CC4OC(c5ccc(Cc6cccc(N)c6)cc5)OC4(C(=O)CO)C3CC(O)C12 |
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InChI |
InChI=1S/C34H37NO6/c1-33-12-11-24(37)15-22(33)9-10-25-26-16-30-34(29(39)18-36,27(26)17-28(38)31(25)33)41-32(40-30)21-7-5-19(6-8-21)13-20-3-2-4-23(35)14-20/h2-8,11-12,14-15,25-28,30-32,36,38H,9-10,13,16-18,35H2,1H3
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InChIKey |
KGDLJHKCSJFVMZ-UHFFFAOYSA-N
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Pharmaceutical Properties | Molecule Weight |
555.671 |
Polar area |
119.08 |
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Complexity |
41 |
xlogp Value |
4.0723 |
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Heavy Count |
41 |
Rot Bonds |
5 |
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Hbond acc |
7 |
Hbond Donor |
3 |
The activity data of This Payload
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
Anti-TNF ADC 107 [Investigative]
Revealed Based on the Cell Line Data
Experiment 1 Reporting the Activity Date of This ADC | [2] | ||||
Efficacy Data | Half Maximal Effective Concentration (EC50) |
7.03 ug/mL
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Positive TNF expression (TNF+++/++) | ||
Method Description |
All the DAR purified ADCs were screened in both the TNF-expressing and wild-type K562 GRE reporter cell assay to confirm that their activity was consistent with ADCs having heterogeneous average DAR.
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In Vitro Model | Erythroleukemia | HEL 92.1.7 cells (Multidrug resistance) | CVCL_2481 | ||
Experiment 2 Reporting the Activity Date of This ADC | [2] | ||||
Efficacy Data | Half Maximal Effective Concentration (EC50) | > 50.00 ug/mL | Negative TNF expression (TNF-) | ||
Method Description |
All the DAR purified ADCs were screened in both the TNF-expressing and wild-type K562 GRE reporter cell assay to confirm that their activity was consistent with ADCs having heterogeneous average DAR.
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In Vitro Model | Chronic myelogenous leukemia | K-562 cells | CVCL_0004 |
References
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