Payload Information
General Information of This Payload
| Payload ID | PAY0BCPMW |
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|---|---|---|---|---|---|---|
| Name | WO2024043319A1 43 payload |
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| Synonyms |
PAY0467
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| Structure |
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| Formula | C59H68N12O9 |
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| Isosmiles | CC(N[C@H](C(NCOC[C@](C1=NC(N2CCC(N3CCC(C)(NCC#CC4=CC=C(OC)C(N(C5=O)CCC(N5)=O)=C4)CC3)CC2)=NC6=C1C=C(C=C6)C7=CN(C(C8=C7C=CN8)=O)C)(OC9CC9)C%10=CC=CC=C%10)=O)CC(N)=O)=O |
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| InChI |
InChI=1S/C59H68N12O9/c1-37(72)64-47(33-50(60)73)54(75)62-36-79-35-59(80-42-14-15-42,40-10-6-5-7-11-40)53-44-32-39(45-34-68(3)55(76)52-43(45)18-25-61-52)13-16-46(44)65-56(67-53)70-26-19-41(20-27-70)69-29-22-58(2,23-30-69)63-24-8-9-38-12-17-49(78-4)48(31-38)71-28-21-51(74)66-57(71)77/h5-7,10-13,16-18,25,31-32,34,41-42,47,61,63H,14-15,19-24,26-30,33,35-36H2,1-4H3,(H2,60,73)(H,62,75)(H,64,72)(H,66,74,77)/t47-,59-/m0/s1
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| InChIKey |
FWJAKBHQCVQWEX-QSNXIGBYSA-N
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| Pharmaceutical Properties | Molecule Weight |
1089.268 |
Polar area |
260.47 |
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Complexity |
3340.068454 |
xlogp Value |
4.2893 |
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Heavy Count |
80 |
Rot Bonds |
19 |
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Hbond acc |
15 |
Hbond Donor |
6 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024043319A1 43 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.07 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||