Payload Information

General Information of This Payload

Payload ID	PAY0ALSVY
Name	Methylated-beta-Cyclodextrin/Pluronic P103-based polyrotaxane (Me-PRX)
Synonyms	Methylated-beta-Cyclodextrin/Pluronic P103-based polyrotaxane (Me-PRX) Click to Show/Hide
Target(s)	.	Target Info

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

Trastuzumab-Me-PRX conjugate [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 3 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	5.50 uM	Negative HER2 expression (HER2-)
Method Description	Cells were plated in 96-well tissue culture plates (SigmaAldrich) 1 day before treatment, serum-starved, and treated with serially diluted Tras-Me-PRX (10 mg/mL antibody) for 24 h.
In Vitro Model	Endocervical adenocarcinoma	HeLa cells		CVCL_0030
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	6.75 uM	Positive HER2 expression (HER2+++/++)
Method Description	Cells were plated in 96-well tissue culture plates (SigmaAldrich) 1 day before treatment, serum-starved, and treated with serially diluted Tras-Me-PRX (10 mg/mL antibody) for 24 h.
In Vitro Model	Lung adenocarcinoma	Calu-3 cells		CVCL_0609
Experiment 3 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	7.02 uM	Positive HER2 expression (HER2+++/++)
Method Description	Cells were plated in 96-well tissue culture plates (SigmaAldrich) 1 day before treatment, serum-starved, and treated with serially diluted Tras-Me-PRX (10 mg/mL antibody) for 24 h.
In Vitro Model	Ovarian serous cystadenocarcinoma	SK-OV-3 cells		CVCL_0532

References

Ref 1	An antibody-supermolecule conjugate for tumor-specific targeting of tumoricidal methylated -cyclodextrin-threaded polyrotaxanes. J Mater Chem B. 2020 Aug 21;8(31):6975-6987. doi: 10.1039/d0tb00575d. Epub 2020 Jun 23.