Payload Information
General Information of This Payload
| Payload ID | PAY0AKQNU |
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|---|---|---|---|---|---|---|
| Name | CL202203715A1 Vlh |
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| Synonyms |
CL202203715A1 Vlh
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| Structure |
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| Formula | C42H67N7O8S |
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| Isosmiles | CCCCON([C@@H](C(C)C)C[C@@H](OC(NC)=O)C1=NC(C(N[C@@H](CC2=CC=C(N)C=C2)CC(C)(C)C(O)=O)=O)=CS1)C([C@@H](NC([C@@H]3N(CCCC3)C)=O)[C@@H](C)CC)=O |
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| InChI |
InChI=1S/C42H67N7O8S/c1-10-12-21-56-49(39(52)35(27(5)11-2)47-37(51)32-15-13-14-20-48(32)9)33(26(3)4)23-34(57-41(55)44-8)38-46-31(25-58-38)36(50)45-30(24-42(6,7)40(53)54)22-28-16-18-29(43)19-17-28/h16-19,25-27,30,32-35H,10-15,20-24,43H2,1-9H3,(H,44,55)(H,45,50)(H,47,51)(H,53,54)/t27-,30-,32+,33+,34+,35-/m0/s1
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| InChIKey |
SOKGOWDPDBPTCW-UOHYYBFCSA-N
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| Pharmaceutical Properties | Molecule Weight |
830.106 |
Polar area |
205.52 |
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Complexity |
1582.17837 |
xlogp Value |
5.9546 |
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Heavy Count |
58 |
Rot Bonds |
22 |
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Hbond acc |
11 |
Hbond Donor |
5 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
TRSQ-ZP3A- LP15-Vlh [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.044 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 46% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||