Payload Information
General Information of This Payload
| Payload ID | PAY0AGEOO |
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| Name | WO2024140449A1+ADC19+payload |
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| Synonyms |
WO2024140449A1+ADC19+payload
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| Structure |
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| Formula | C36H35N5O10 |
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| Isosmiles | CC[C@]1(OC(NNC2=CC=C(C(O)=O)C=C2)=O)C(C=C3C4=NC5=CC6=C(OCO6)C=C5C(CCNC7CCOCC7)=C4CN83)=C(COC1=O)C8=O |
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| InChI |
InChI=1S/C36H35N5O10/c1-2-36(51-35(46)40-39-21-5-3-19(4-6-21)33(43)44)26-14-28-31-24(16-41(28)32(42)25(26)17-48-34(36)45)22(7-10-37-20-8-11-47-12-9-20)23-13-29-30(50-18-49-29)15-27(23)38-31/h3-6,13-15,20,37,39H,2,7-12,16-18H2,1H3,(H,40,46)(H,43,44)/t36-/m0/s1
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| InChIKey |
KDGGAZFOPITILD-BHVANESWSA-N
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| Pharmaceutical Properties | Molecule Weight |
697.701 |
Polar area |
188.57 |
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Complexity |
2085.243316 |
xlogp Value |
3.5786 |
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Heavy Count |
51 |
Rot Bonds |
9 |
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Hbond acc |
13 |
Hbond Donor |
4 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
wO2024140449A1 ADC20 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 5 nM | |||
| Method Description |
A Cell line test onNCI-H1975
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| In Vitro Model | Lung adenocarcinoma | NCI-H1975 cells | CVCL_1511 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 5 nM | |||
| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||