Linker Information
General Information of This Linker
| Linker ID |
LIN0ZYGKS
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
WO2023173026A1-ADC-L078-121-Linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C40H58N8O10S2
|
|||||
| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(C1=CC=C(N=C(C(CS)=N2)CS)C2=C1)=O)=O)C(NC(CCCNC(N)=O)C(NC3=CC=C(CO)C=C3)=O)=O)C
|
|||||
| InChI |
InChI=1S/C40H58N8O10S2/c1-26(2)36(39(53)47-31(4-3-12-43-40(41)54)38(52)44-29-8-5-27(23-49)6-9-29)48-35(50)11-14-55-16-18-57-20-21-58-19-17-56-15-13-42-37(51)28-7-10-30-32(22-28)46-34(25-60)33(24-59)45-30/h5-10,22,26,31,36,49,59-60H,3-4,11-21,23-25H2,1-2H3,(H,42,51)(H,44,52)(H,47,53)(H,48,50)(H3,41,43,54)/t31?,36-/m0/s1
|
|||||
| InChIKey |
FIEAVKZCERUXDN-TVQXPHSOSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
875.084
|
Polar area
|
254.45
|
||
|
Complexity
|
1740.515789
|
xlogp Value
|
1.8808
|
|||
|
Heavy Count
|
60
|
Rot Bonds
|
29
|
|||
|
Hbond acc
|
14
|
Hbond Donor
|
9
|
|||
Each Antibody-drug Conjugate Related to This Linker