Linker Information
General Information of This Linker
| Linker ID |
LIN0ZYFZG
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| Linker Name |
T-1-AB Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C50H64N6O23S
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| Isosmiles |
COC(C1=CC(C(/C=C/C(N)=O)=O)=CC(C(NCCOCCOCCOCC2=CN(N=N2)CCOCCOCCOCCNC(C3=CC(OS(=O)(OC4=CC=C(C=C4)CO)=O)=C(OC5[C@H](O)[C@@H](O)[C@@H](O)[C@H](O5)CO)C=C3)=O)=O)=C1)=O
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| InChI |
InChI=1S/C50H64N6O23S/c1-69-49(66)36-25-34(39(59)7-9-43(51)60)24-35(26-36)48(65)53-11-14-71-17-20-74-22-23-75-31-37-28-56(55-54-37)12-15-72-18-21-73-19-16-70-13-10-52-47(64)33-4-8-40(76-50-46(63)45(62)44(61)42(30-58)77-50)41(27-33)79-80(67,68)78-38-5-2-32(29-57)3-6-38/h2-9,24-28,42,44-46,50,57-58,61-63H,10-23,29-31H2,1H3,(H2,51,60)(H,52,64)(H,53,65)/b9-7+/t42-,44+,45+,46-,50?/m1/s1
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| InChIKey |
DITOUTPUHFHFHZ-ZQVKLNGWSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1149.148
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Polar area
|
402.96
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Complexity
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2658.204998
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xlogp Value
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-1.8779
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Heavy Count
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80
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Rot Bonds
|
37
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Hbond acc
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26
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker