Linker Information
General Information of This Linker
| Linker ID |
LIN0ZUQLU
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| Linker Name |
ThioBridge- (VCP)2 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C176H297N15O116S2
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| Isosmiles |
CC1=CC=C(S(CC(CS(C(C=C2)=CC=C2C)(=O)=O)C(C3=CC=C(C(N[C@@H](CCC(N[C@@H](C(C)C)C(N[C@H](C(NC4=CC=C(COC(O)=O)C=C4)=O)CCCNC(N)=O)=O)=O)C(N[C@H](C(N[C@@H](CCC(NCCOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOC)=O)C(NCCOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOOCCOC)=O)=O)CCC(N[C@H](C(N[C@H](C(NC5=CC=C(COC(O)=O)C=C5)=O)CCCNC(N)=O)=O)C(C)C)=O)=O)=O)C=C3)=O)(=O)=O)C=C1
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| InChI |
InChI=1S/C176H297N15O116S2/c1-141(2)162(171(202)188-154(11-9-39-181-173(177)204)167(198)183-150-25-17-145(18-26-150)137-218-175(206)207)190-160(193)37-34-157(185-165(196)148-23-21-147(22-24-148)164(195)149(139-308(210,211)152-29-13-143(5)14-30-152)140-309(212,213)153-31-15-144(6)16-32-153)169(200)187-158(35-38-161(194)191-163(142(3)4)172(203)189-155(12-10-40-182-174(178)205)168(199)184-151-27-19-146(20-28-151)138-219-176(208)209)170(201)186-156(166(197)180-42-44-217-48-52-223-227-56-60-231-235-64-68-239-243-72-76-247-251-80-84-255-259-88-92-263-267-96-100-271-275-104-108-279-283-112-116-287-291-120-124-295-299-128-132-303-307-136-134-305-301-130-126-297-293-122-118-289-285-114-110-281-277-106-102-273-269-98-94-265-261-90-86-257-253-82-78-249-245-74-70-241-237-66-62-233-229-58-54-225-221-50-46-215-8)33-36-159(192)179-41-43-216-47-51-222-226-55-59-230-234-63-67-238-242-71-75-246-250-79-83-254-258-87-91-262-266-95-99-270-274-103-107-278-282-111-115-286-290-119-123-294-298-127-131-302-306-135-133-304-300-129-125-296-292-121-117-288-284-113-109-280-276-105-101-272-268-97-93-264-260-89-85-256-252-81-77-248-244-73-69-240-236-65-61-232-228-57-53-224-220-49-45-214-7/h13-32,141-142,149,154-158,162-163H,9-12,33-140H2,1-8H3,(H,179,192)(H,180,197)(H,183,198)(H,184,199)(H,185,196)(H,186,201)(H,187,200)(H,188,202)(H,189,203)(H,190,193)(H,191,194)(H,206,207)(H,208,209)(H3,177,181,204)(H3,178,182,205)/t154-,155-,156-,157-,158-,162-,163-/m0/s1
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| InChIKey |
ZQBUGCWUJYVJGG-GZDZUOJJSA-N
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| Pharmaceutical Properties |
Molecule Weight
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4543.435
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Polar area
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1457.91
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Complexity
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.
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xlogp Value
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0.55274
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Heavy Count
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309
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Rot Bonds
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236
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Hbond acc
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114
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Hbond Donor
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17
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Each Antibody-drug Conjugate Related to This Linker