Linker Information
General Information of This Linker
| Linker ID |
LIN0ZOKVO
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| Linker Name |
CN119630431A-ADC-27-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C34H33N5O8S2
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| Isosmiles |
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)=O)CCN2C(C(SC3=CC=CC=C3)=C(SC4=CC=CC=C4)C2=O)=O
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| InChI |
InChI=1S/C34H33N5O8S2/c40-26(35-19-27(41)36-20-28(42)38-25(32(45)37-21-29(43)44)18-22-10-4-1-5-11-22)16-17-39-33(46)30(48-23-12-6-2-7-13-23)31(34(39)47)49-24-14-8-3-9-15-24/h1-15,25H,16-21H2,(H,35,40)(H,36,41)(H,37,45)(H,38,42)(H,43,44)/t25-/m0/s1
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| InChIKey |
YZZSLZJZXDXCDS-VWLOTQADSA-N
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| Pharmaceutical Properties |
Molecule Weight
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703.799
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Polar area
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191.08
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Complexity
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1593.997188
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xlogp Value
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1.7022
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Heavy Count
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49
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Rot Bonds
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17
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Hbond acc
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9
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 16 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.035 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||