Linker Information
General Information of This Linker
| Linker ID |
LIN0ZMRPG
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| Linker Name |
MC-Val-Cit-RG-1
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C38H50N8O10
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| Isosmiles |
O=C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(NCC2=CC=CC=C2N(C)C(O)=O)=O)C=C1)=O)[C@H](C(C)C)NC(CCCCCN3C(C=CC3=O)=O)=O
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| InChI |
InChI=1S/C38H50N8O10/c1-24(2)33(44-30(47)13-5-4-8-21-46-31(48)18-19-32(46)49)35(51)43-28(11-9-20-40-36(39)52)34(50)42-27-16-14-25(15-17-27)23-56-37(53)41-22-26-10-6-7-12-29(26)45(3)38(54)55/h6-7,10,12,14-19,24,28,33H,4-5,8-9,11,13,20-23H2,1-3H3,(H,41,53)(H,42,50)(H,43,51)(H,44,47)(H,54,55)(H3,39,40,52)/t28-,33-/m0/s1
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| InChIKey |
HKGHUCZGQBTMSF-UVMMSNCQSA-N
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| Pharmaceutical Properties |
Molecule Weight
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778.864
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Polar area
|
258.67
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Complexity
|
1678.07027
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xlogp Value
|
2.7252
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Heavy Count
|
56
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Rot Bonds
|
21
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Hbond acc
|
9
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker