Linker Information
General Information of This Linker
| Linker ID |
LIN0ZMJRK
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| Linker Name |
Aminobenzazepine-linker Formula II-31
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C47H66F4N2O24
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| Isosmiles |
FC1=CC(F)=C(F)C(OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCCC(NC2=CC(COC(O)=O)=CC=C2O[C@H](O3)[C@H](O)[C@@H](O)[C@H](O)[C@H]3C(O)=O)=O)=O)=O)=C1F
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| InChI |
InChI=1S/C47H66F4N2O24/c48-31-28-32(49)39(51)43(38(31)50)76-37(56)5-8-65-10-12-67-14-16-69-18-20-71-22-24-73-26-25-72-23-21-70-19-17-68-15-13-66-11-9-64-7-4-35(54)52-6-3-36(55)53-33-27-30(29-74-47(62)63)1-2-34(33)75-46-42(59)40(57)41(58)44(77-46)45(60)61/h1-2,27-28,40-42,44,46,57-59H,3-26,29H2,(H,52,54)(H,53,55)(H,60,61)(H,62,63)/t40-,41-,42+,44-,46+/m0/s1
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| InChIKey |
RWWHVSQLCFURFG-YPUPTSRNSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1119.027
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Polar area
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339.78
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Complexity
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1936.428876
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xlogp Value
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0.7052
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Heavy Count
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77
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Rot Bonds
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43
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Hbond acc
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22
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Hbond Donor
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7
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-20 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
788 nM
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| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||