Linker Information
General Information of This Linker
| Linker ID |
LIN0ZLYAJ
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| Linker Name |
DIBAC-PEG4 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C41H57N7O10
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| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(CCC(N1C2=C(C#CC(C=CC=C3)=C3C1)C=CC=C2)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(N)=O)=O)C
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| InChI |
InChI=1S/C41H57N7O10/c1-29(2)38(40(53)46-33(39(42)52)11-7-18-45-41(43)54)47-36(50)17-20-55-22-24-57-26-27-58-25-23-56-21-19-44-35(49)15-16-37(51)48-28-32-10-4-3-8-30(32)13-14-31-9-5-6-12-34(31)48/h3-6,8-10,12,29,33,38H,7,11,15-28H2,1-2H3,(H2,42,52)(H,44,49)(H,46,53)(H,47,50)(H3,43,45,54)/t33-,38-/m0/s1
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| InChIKey |
NRFUVIQMSIYOPS-BAOFOTJISA-N
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| Pharmaceutical Properties |
Molecule Weight
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807.946
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Polar area
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242.74
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Complexity
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1660.535962
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xlogp Value
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0.8453
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Heavy Count
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58
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Rot Bonds
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27
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Hbond acc
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10
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A- LP6-Vb [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.046 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 43% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
TRSQ-ZP3A-LP22 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.376 nM
|
Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 27% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
TRSQ-ZP3A-LP24 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
2.733 nM
|
Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 30% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
CTRL-ZP3A-LP24 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
321.547 nM
|
Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 31% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
CTRL-ZP3A-LP22 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
461.721 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 28% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||