Linker Information
General Information of This Linker
| Linker ID |
LIN0ZLCBW
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| Linker Name |
WO2024020536A1+HER-E-48+Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C26H33N5O8
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| Isosmiles |
CN(CC(O)=O)C([C@@H](NC(CNC(CNC(CCCCCN1C(C=CC1=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O
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| InChI |
InChI=1S/C26H33N5O8/c1-30(17-25(37)38)26(39)19(14-18-8-4-2-5-9-18)29-22(34)16-28-21(33)15-27-20(32)10-6-3-7-13-31-23(35)11-12-24(31)36/h2,4-5,8-9,11-12,19H,3,6-7,10,13-17H2,1H3,(H,27,32)(H,28,33)(H,29,34)(H,37,38)/t19-/m0/s1
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| InChIKey |
PITNTXULYUAYNL-IBGZPJMESA-N
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| Pharmaceutical Properties |
Molecule Weight
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543.577
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Polar area
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182.29
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Complexity
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1038.515346
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xlogp Value
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-1.0253
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Heavy Count
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39
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Rot Bonds
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16
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Hbond acc
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7
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
HER-E-48 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
109.2 pM
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High HER2 expression (HER2 +++) | ||
| Method Description |
A Cell line test on SKBR-3
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||