Linker Information
General Information of This Linker
| Linker ID |
LIN0ZJNZD
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| Linker Name |
Trastuzumab-LD8-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C32H50N6O8
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| Isosmiles |
CN(C(OCC1=CC=C(NC([C@@H](NC([C@H](C(C)C)N(C)C)=O)CCCCN(C(C=C2)=O)C2=O)=O)C=C1)=O)CCNCCOCCO
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| InChI |
InChI=1S/C32H50N6O8/c1-23(2)29(36(3)4)31(43)35-26(8-6-7-17-38-27(40)13-14-28(38)41)30(42)34-25-11-9-24(10-12-25)22-46-32(44)37(5)18-15-33-16-20-45-21-19-39/h9-14,23,26,29,33,39H,6-8,15-22H2,1-5H3,(H,34,42)(H,35,43)/t26-,29-/m0/s1
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| InChIKey |
ULKAIXFGDQEYRB-WNJJXGMVSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
646.786
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Polar area
|
169.85
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Complexity
|
1093.074443
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xlogp Value
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0.9583
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Heavy Count
|
46
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Rot Bonds
|
21
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Hbond acc
|
10
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Hbond Donor
|
4
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Each Antibody-drug Conjugate Related to This Linker