Linker Information
General Information of This Linker
| Linker ID |
LIN0ZIYJJ
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| Linker Name |
WO2023173026A1-ADC-L078-117-Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C34H50N6O11
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| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(C1=CC=C(N)C(N)=C1)=O)=O)C(N[C@@H](C)C(NC2=CC=C(C=C2)COC(O)=O)=O)=O)C
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| InChI |
InChI=1S/C34H50N6O11/c1-22(2)30(33(44)38-23(3)31(42)39-26-7-4-24(5-8-26)21-51-34(45)46)40-29(41)10-12-47-14-16-49-18-19-50-17-15-48-13-11-37-32(43)25-6-9-27(35)28(36)20-25/h4-9,20,22-23,30H,10-19,21,35-36H2,1-3H3,(H,37,43)(H,38,44)(H,39,42)(H,40,41)(H,45,46)/t23-,30-/m0/s1
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| InChIKey |
ZJESAIBKDWPOSJ-JHOBJCJYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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718.805
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Polar area
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251.89
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Complexity
|
1344.907185
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xlogp Value
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1.5161
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Heavy Count
|
51
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Rot Bonds
|
24
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Hbond acc
|
12
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker