Linker Information
General Information of This Linker
| Linker ID |
LIN0ZFKFN
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| Linker Name |
CN116916962A-C-38-linker
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C43H69N5O15
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOC)=O)CCCCN1C(C=CC1=O)=O)=O)C(N[C@@H](C)C(NC2=CC=C(C=C2)CO)=O)=O)C
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| InChI |
InChI=1S/C43H69N5O15/c1-32(2)40(43(55)44-33(3)41(53)45-35-10-8-34(31-49)9-11-35)47-42(54)36(7-5-6-15-48-38(51)12-13-39(48)52)46-37(50)14-16-57-19-20-59-23-24-61-27-28-63-30-29-62-26-25-60-22-21-58-18-17-56-4/h8-13,32-33,36,40,49H,5-7,14-31H2,1-4H3,(H,44,55)(H,45,53)(H,46,50)(H,47,54)/t33-,36-,40-/m0/s1
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| InChIKey |
SKFKNSJLFJVVGR-HLSLCHRCSA-N
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| Pharmaceutical Properties |
Molecule Weight
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896.045
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Polar area
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247.85
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Complexity
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1422.872652
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xlogp Value
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0.4957
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Heavy Count
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63
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Rot Bonds
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38
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Hbond acc
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15
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CN116916962A-ADC-B17 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
1.14 nM
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High hCCR2 expression (hCCR2+++) | ||
| Method Description |
THP 1, 15,000cells/254uL per welld were plated at set in 384 well flat plate, in the appropriate growth media. The cell plates were dosed with 5uL of the hCCR2 targeting-ADC samples and then incubated at 37°C for 20 hours. At the end of the incubation 10uL/well of the QUANTJ-LucTM (InvivoGenftrep-qlc1) were added and luminescence was measured immediately using the LeadSeeker.
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP1 cells | CVCL_0006 | ||