Linker Information
General Information of This Linker
| Linker ID |
LIN0ZETXE
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|---|---|---|---|---|---|---|
| Linker Name |
Mc-Asn-Pro-Val-PABC
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C31H42N6O8
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| Isosmiles |
CC(C)C(NC(=O)C1CCCN1C(=O)C(CC(N)=O)NC(=O)CCCCCN1C(=O)C=CC1=O)C(=O)Nc1ccc(CO)cc1
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| InChI |
InChI=1S/C31H42N6O8/c1-19(2)28(30(44)33-21-11-9-20(18-38)10-12-21)35-29(43)23-7-6-16-36(23)31(45)22(17-24(32)39)34-25(40)8-4-3-5-15-37-26(41)13-14-27(37)42/h9-14,19,22-23,28,38H,3-8,15-18H2,1-2H3,(H2,32,39)(H,33,44)(H,34,40)(H,35,43)
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| InChIKey |
ZHNFRWMVPCKBMI-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
626.711
|
Polar area
|
208.31
|
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Complexity
|
45
|
xlogp Value
|
0.0948
|
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Heavy Count
|
45
|
Rot Bonds
|
16
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Hbond acc
|
8
|
Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker
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