Linker Information
General Information of This Linker
| Linker ID |
LIN0ZDTFK
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| Linker Name |
CN119630431A-ADC-38-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C31H34N4O11S2
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| Isosmiles |
O=C(O)C[C@H](NC([C@@H](NC(CCOCCOCCN1C(C(SC2=CC=CC=C2)=C(SC3=CC=CC=C3)C1=O)=O)=O)CC(N)=O)=O)C(O)=O
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| InChI |
InChI=1S/C31H34N4O11S2/c32-23(36)17-21(28(40)34-22(31(43)44)18-25(38)39)33-24(37)11-13-45-15-16-46-14-12-35-29(41)26(47-19-7-3-1-4-8-19)27(30(35)42)48-20-9-5-2-6-10-20/h1-10,21-22H,11-18H2,(H2,32,36)(H,33,37)(H,34,40)(H,38,39)(H,43,44)/t21-,22-/m0/s1
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| InChIKey |
YKKKIWWPFDFFPS-VXKWHMMOSA-N
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| Pharmaceutical Properties |
Molecule Weight
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702.764
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Polar area
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231.73
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Complexity
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1392.896425
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xlogp Value
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0.979
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Heavy Count
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48
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Rot Bonds
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21
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Hbond acc
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11
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 27 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 0.015 nM | Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||