Linker Information
General Information of This Linker
| Linker ID |
LIN0ZAXHQ
|
|||||
|---|---|---|---|---|---|---|
| Name |
Mal-PEG4-Val-Lys (PEG24)-Cit-PAB
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C85H155N7O36
|
|||||
| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(CCN1C(CCC1=O)=O)=O)=O)C(N[C@@H](CCCNC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)C(NC2=CC=C(CO)C=C2)=O)=O)C
|
|||||
| InChI |
InChI=1S/C85H155N7O36/c1-74(2)82(91-79(95)13-18-102-23-26-106-31-32-107-27-24-103-19-15-86-78(94)12-17-92-80(96)10-11-81(92)97)84(99)90-77(83(98)89-76-8-6-75(73-93)7-9-76)5-4-14-87-85(100)88-16-20-104-25-28-108-33-34-110-37-38-112-41-42-114-45-46-116-49-50-118-53-54-120-57-58-122-61-62-124-65-66-126-69-70-128-72-71-127-68-67-125-64-63-123-60-59-121-56-55-119-52-51-117-48-47-115-44-43-113-40-39-111-36-35-109-30-29-105-22-21-101-3/h6-9,74,77,82,93H,4-5,10-73H2,1-3H3,(H,86,94)(H,89,98)(H,90,99)(H,91,95)(H2,87,88,100)/t77-,82-/m0/s1
|
|||||
| InChIKey |
KADMGGQRFDVLAV-RXLCXJEYSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1851.188
|
Polar area
|
473.58
|
||
|
Complexity
|
.
|
xlogp Value
|
-0.0376
|
|||
|
Heavy Count
|
128
|
Rot Bonds
|
101
|
|||
|
Hbond acc
|
36
|
Hbond Donor
|
7
|
|||
Each Antibody-drug Conjugate Related to This Linker