Linker Information
General Information of This Linker
| Linker ID |
LIN0ZAFUV
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| Linker Name |
H1H21234N-N297Q- LP9 lINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C57H83N11O13
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| Isosmiles |
NCCOCCOCCCCCN(N=N1)C(C2=C3C=CC=C2)=C1C4=C(N(C(CCC(NCCOCCOCCOCCOCCC(N[C@H](C(C)C)C(N[C@H](C(NC5=CC=C(CO)C=C5)=O)CCCNC(N)=O)=O)=O)=O)=O)C3)C=CC=C4
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| InChI |
InChI=1S/C57H83N11O13/c1-41(2)52(56(74)63-47(14-10-24-61-57(59)75)55(73)62-44-18-16-42(40-69)17-19-44)64-50(71)22-28-77-32-35-80-37-38-81-36-34-79-30-25-60-49(70)20-21-51(72)67-39-43-11-4-5-12-45(43)54-53(46-13-6-7-15-48(46)67)65-66-68(54)26-8-3-9-27-76-31-33-78-29-23-58/h4-7,11-13,15-19,41,47,52,69H,3,8-10,14,20-40,58H2,1-2H3,(H,60,70)(H,62,73)(H,63,74)(H,64,71)(H3,59,61,75)/t47-,52+/m0/s1
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| InChIKey |
UFQYMWUKEAFRAR-SMTSAFDASA-N
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| Pharmaceutical Properties |
Molecule Weight
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1130.355
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Polar area
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324.17
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Complexity
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2453.905066
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xlogp Value
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3.1789
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Heavy Count
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81
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Rot Bonds
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40
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Hbond acc
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17
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Hbond Donor
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8
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
H1H21234N-N297Q-LP9 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.414 nM
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Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-4/LXR-Luc cells
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||