Linker Information
General Information of This Linker
| Linker ID |
LIN0ZADNU
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|---|---|---|---|---|---|---|
| Name |
Mal-Gly (glucose)-Val-Cit-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C40H58N10O13
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| Isosmiles |
CC([C@H](CNC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CC(N=N2)=CN2[C@H](O3)[C@H](O)[C@@H](O)[C@H](O)[C@H]3CO)=O)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(CO)C=C4)=O)=O)C
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| InChI |
InChI=1S/C40H58N10O13/c1-22(2)26(36(59)46-27(7-6-15-42-40(41)62)38(61)44-24-11-9-23(20-51)10-12-24)18-43-37(60)28(45-30(53)8-4-3-5-16-49-31(54)13-14-32(49)55)17-25-19-50(48-47-25)39-35(58)34(57)33(56)29(21-52)63-39/h9-14,19,22,26-29,33-35,39,51-52,56-58H,3-8,15-18,20-21H2,1-2H3,(H,43,60)(H,44,61)(H,45,53)(H,46,59)(H3,41,42,62)/t26-,27-,28-,29+,33+,34-,35+,39+/m0/s1
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| InChIKey |
QFZQKSJGOAOSIU-TVCFAXMBSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
886.961
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Polar area
|
349.99
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Complexity
|
1824.269355
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xlogp Value
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-2.7841
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Heavy Count
|
63
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Rot Bonds
|
24
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Hbond acc
|
16
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Hbond Donor
|
11
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Each Antibody-drug Conjugate Related to This Linker