Linker Information
General Information of This Linker
| Linker ID |
LIN0YZFZP
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| Linker Name |
WO2024020536A1+HER-E-36+Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C12H16N2O5
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| Isosmiles |
O=C(O)CNC(CCCCCN1C(C=CC1=O)=O)=O
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| PubChem CID | ||||||
| InChI |
InChI=1S/C12H16N2O5/c15-9(13-8-12(18)19)4-2-1-3-7-14-10(16)5-6-11(14)17/h5-6H,1-4,7-8H2,(H,13,15)(H,18,19)
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| InChIKey |
XKOJYRKNXZOQHX-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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268.269
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Polar area
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103.78
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Complexity
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374.2613731
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xlogp Value
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-0.3274
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Heavy Count
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19
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Rot Bonds
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8
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Hbond acc
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4
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Hbond Donor
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2
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
HER-E-36 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
790.08 pM
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High HER2 expression (HER2 +++) | ||
| Method Description |
A Cell line test on SKBR-3
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||