Linker Information
General Information of This Linker
| Linker ID |
LIN0YYVHB
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|---|---|---|---|---|---|---|
| Linker Name |
DIBAC-suc-PEG4-Val-Cit-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C61H89N11O19S
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| Isosmiles |
CC(C)C(NC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCC(=O)NCCS(=O)(=O)O)c2-c2ccccc21)C(=O)NC(CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1
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| InChI |
InChI=1S/C61H89N11O19S/c1-44(2)56(60(79)67-50(11-7-21-65-61(62)80)59(78)66-47-15-13-45(43-73)14-16-47)68-54(76)20-26-85-30-34-89-37-39-90-35-31-86-27-22-63-52(74)17-18-55(77)71-42-46-8-3-4-9-48(46)57-58(49-10-5-6-12-51(49)71)72(70-69-57)24-28-87-32-36-91-40-38-88-33-29-84-25-19-53(75)64-23-41-92(81,82)83/h3-6,8-10,12-16,44,50,56,73H,7,11,17-43H2,1-2H3,(H,63,74)(H,64,75)(H,66,78)(H,67,79)(H,68,76)(H3,62,65,80)(H,81,82,83)
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| InChIKey |
QCHBPJRWBFAFHE-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1312.508
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Polar area
|
400.08
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Complexity
|
92
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xlogp Value
|
1.4772
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Heavy Count
|
92
|
Rot Bonds
|
47
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Hbond acc
|
21
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker
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