Linker Information
General Information of This Linker
| Linker ID |
LIN0YXWEC
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|---|---|---|---|---|---|---|
| Linker Name |
Bis-bromine linker-mono-glycine-PEG12-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C57H90Br2N6O19
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCCC(NC(=O)CCOCCNC(=O)c1ccc2nc(CBr)c(CBr)nc2c1)C(=O)Nc1ccc(CO)cc1
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| InChI |
InChI=1S/C57H90Br2N6O19/c1-71-18-19-74-22-23-76-26-27-78-30-31-80-34-35-82-38-39-84-41-40-83-37-36-81-33-32-79-29-28-77-25-24-75-21-20-73-15-11-54(67)60-13-3-2-4-50(57(70)62-48-8-5-46(45-66)6-9-48)65-55(68)12-16-72-17-14-61-56(69)47-7-10-49-51(42-47)64-53(44-59)52(43-58)63-49/h5-10,42,50,66H,2-4,11-41,43-45H2,1H3,(H,60,67)(H,61,69)(H,62,70)(H,65,68)
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| InChIKey |
SAZRYDWSYQUFDW-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1323.178
|
Polar area
|
291.63
|
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Complexity
|
84
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xlogp Value
|
3.6941
|
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Heavy Count
|
84
|
Rot Bonds
|
57
|
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|
Hbond acc
|
21
|
Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker
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