Linker Information
General Information of This Linker
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
ADC Trast-11 [Investigative]
Revealed Based on the Cell Line Data
Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.02 nM
|
High HER2 expression (HER2+++) | ||
Method Description |
In vitro cytotoxicity of ADCs against a panel of four human breast cancer cell lines.
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In Vitro Model | Breast ductal carcinoma | HCC1954 cells | CVCL_1259 | ||
Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 100 nM | Negative HER2 expression (HER2-) | ||
Method Description |
In vitro cytotoxicity of ADCs against a panel of four human breast cancer cell lines.
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In Vitro Model | Breast adenocarcinoma | MDA-MB-231 cells | CVCL_0062 |
ADC Trast-10 [Investigative]
Revealed Based on the Cell Line Data
Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.30 nM
|
High HER2 expression (HER2+++) | ||
Method Description |
In vitro cytotoxicity of ADCs against a panel of four human breast cancer cell lines.
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In Vitro Model | Invasive breast carcinoma | BT-474 cells | CVCL_0179 | ||
Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 100 nM | Negative HER2 expression (HER2-) | ||
Method Description |
In vitro cytotoxicity of ADCs against a panel of four human breast cancer cell lines.
|
||||
In Vitro Model | Breast adenocarcinoma | MDA-MB-231 cells | CVCL_0062 |
References
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