General Information of This Linker
Linker ID
LIN0YWETK
Linker Name
Bis-BCN-modified Val-Cit-PABC linker 10
Linker Type
Bioorthogonal reaction linker
Antibody-Linker Relation
Cleavable
Structure
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
ADC Trast-11 [Investigative]
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.02 nM
High HER2 expression (HER2+++)
Method Description
In vitro cytotoxicity of ADCs against a panel of four human breast cancer cell lines.
In Vitro Model Breast ductal carcinoma HCC1954 cells CVCL_1259
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50) > 100 nM Negative HER2 expression (HER2-)
Method Description
In vitro cytotoxicity of ADCs against a panel of four human breast cancer cell lines.
In Vitro Model Breast adenocarcinoma MDA-MB-231 cells CVCL_0062
ADC Trast-10 [Investigative]
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.30 nM
High HER2 expression (HER2+++)
Method Description
In vitro cytotoxicity of ADCs against a panel of four human breast cancer cell lines.
In Vitro Model Invasive breast carcinoma BT-474 cells CVCL_0179
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50) > 100 nM Negative HER2 expression (HER2-)
Method Description
In vitro cytotoxicity of ADCs against a panel of four human breast cancer cell lines.
In Vitro Model Breast adenocarcinoma MDA-MB-231 cells CVCL_0062
References
Ref 1 Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology. Bioconjug Chem. 2023 Mar 15;34(3):538-548. doi: 10.1021/acs.bioconjchem.2c00611. Epub 2023 Mar 1.

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