Linker Information
General Information of This Linker
| Linker ID |
LIN0YNLJT
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| Linker Name |
PEG2000-NHS
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| Linker Type |
Uncleavable linker
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| Antibody-Linker Relation |
Uncleavable
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CD19 mAb-TP [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
6.13 nM
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Positive CD19 expression (CD19+++/++) | ||
| Method Description |
Cells were treated with corresponding agents with various concentrations for 12 or 48 h, and cell viability was detected by MTT (C0009M, Beyotime) assay. Dose-response curves were fitted by GraphPad Prism 9 software. Then, IC50 values were calculated.
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| In Vitro Model | Normal | CHO cells (CD19+) | CVCL_0213 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
27.21 uM
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Negative CD19 expression (CD19-) | ||
| Method Description |
Cells were treated with corresponding agents with various concentrations for 12 or 48 h, and cell viability was detected by MTT (C0009M, Beyotime) assay. Dose-response curves were fitted by GraphPad Prism 9 software. Then, IC50 values were calculated.
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| In Vitro Model | Normal | CHO cells (CD19-) | CVCL_0213 | ||
References