Linker Information
General Information of This Linker
| Linker ID |
LIN0YJNOF
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| Linker Name |
Trastuzumab-LD1-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C35H56N8O12
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| Isosmiles |
CN(C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(OCCOCCN2C(CCC2=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C1)=O)CCNCCOCCO
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| InChI |
InChI=1S/C35H56N8O12/c1-24(2)30(41-34(50)54-22-21-53-19-16-43-28(45)10-11-29(43)46)32(48)40-27(5-4-12-38-33(36)49)31(47)39-26-8-6-25(7-9-26)23-55-35(51)42(3)15-13-37-14-18-52-20-17-44/h6-9,24,27,30,37,44H,4-5,10-23H2,1-3H3,(H,39,47)(H,40,48)(H,41,50)(H3,36,38,49)/t27-,30-/m0/s1
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| InChIKey |
IEYVXLIXCZMLMJ-FIBWVYCGSA-N
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| Pharmaceutical Properties |
Molecule Weight
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780.877
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Polar area
|
269.29
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Complexity
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1310.250834
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xlogp Value
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-0.3583
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Heavy Count
|
55
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Rot Bonds
|
26
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Hbond acc
|
13
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker