Linker Information
General Information of This Linker
| Linker ID |
LIN0YGNWB
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|---|---|---|---|---|---|---|
| Name |
Mal-PEG4-Lys (PEG24)-Cit-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C35H52N8O11
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| Isosmiles |
CC([C@H](NC(CCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NCCOCCC(NC2=CC=C(CO)C=C2)=O)=O)=O)C
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| InChI |
InChI=1S/C35H52N8O11/c1-23(2)32(42-29(47)13-19-53-20-15-37-27(45)11-17-43-30(48)9-10-31(43)49)34(51)41-26(4-3-14-39-35(36)52)33(50)38-16-21-54-18-12-28(46)40-25-7-5-24(22-44)6-8-25/h5-10,23,26,32,44H,3-4,11-22H2,1-2H3,(H,37,45)(H,38,50)(H,40,46)(H,41,51)(H,42,47)(H3,36,39,52)/t26-,32-/m0/s1
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| InChIKey |
JVYREYFSAWXXCV-IEWVHIKDSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
760.846
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Polar area
|
276.69
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Complexity
|
1381.989643
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xlogp Value
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-1.4476
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Heavy Count
|
54
|
Rot Bonds
|
26
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Hbond acc
|
11
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker