Linker Information
General Information of This Linker
| Linker ID |
LIN0YGKJI
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| Linker Name |
L18 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C182H330N18O79
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| Isosmiles |
CC(C)[C@@H](NC(CCOCCOCCNC([C@H](CCCCNC(CCOCCOCCOCCOCCN1C(C=CC1=O)=O)=O)NC(CCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@H](C(NC2=CC(CN(C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)C)=C(O)C=C2)=O)CCCNC(N)=O)=O)=O)=O)=O)=O)C(N[C@@H](C(NC3=CC(CN(C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)C)=C(O)C=C3)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C182H330N18O79/c1-153(2)172(177(216)194-160(12-9-27-187-179(183)218)175(214)191-157-14-16-162(201)155(149-157)151-198(5)181(220)189-30-40-229-50-58-237-66-71-242-75-79-246-83-87-250-91-95-254-99-103-258-107-111-262-115-119-266-123-127-270-131-135-274-139-143-278-147-145-276-141-137-272-133-129-268-125-121-264-117-113-260-109-105-256-101-97-252-93-89-248-85-81-244-77-73-240-69-64-235-56-47-226-37-24-170(209)210)196-166(205)22-35-224-43-49-228-39-29-186-174(213)159(11-7-8-26-185-164(203)20-33-222-44-53-232-63-68-239-60-52-231-42-32-200-168(207)18-19-169(200)208)193-165(204)21-34-223-45-54-233-61-62-234-55-46-225-36-23-167(206)197-173(154(3)4)178(217)195-161(13-10-28-188-180(184)219)176(215)192-158-15-17-163(202)156(150-158)152-199(6)182(221)190-31-41-230-51-59-238-67-72-243-76-80-247-84-88-251-92-96-255-100-104-259-108-112-263-116-120-267-124-128-271-132-136-275-140-144-279-148-146-277-142-138-273-134-130-269-126-122-265-118-114-261-110-106-257-102-98-253-94-90-249-86-82-245-78-74-241-70-65-236-57-48-227-38-25-171(211)212/h14-19,149-150,153-154,159-161,172-173,201-202H,7-13,20-148,151-152H2,1-6H3,(H,185,203)(H,186,213)(H,189,220)(H,190,221)(H,191,214)(H,192,215)(H,193,204)(H,194,216)(H,195,217)(H,196,205)(H,197,206)(H,209,210)(H,211,212)(H3,183,187,218)(H3,184,188,219)/t159-,160+,161-,172+,173-/m0/s1
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| InChIKey |
GNRUECPUOGPQIU-KMVDBCSLSA-N
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| Pharmaceutical Properties |
Molecule Weight
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4034.689
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Polar area
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1124.6
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Complexity
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.
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xlogp Value
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-0.6089
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Heavy Count
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279
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Rot Bonds
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220
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Hbond acc
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77
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Hbond Donor
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19
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CD74 Milatuzumab DANAPAE152C S375C-P1-L18-P2 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.118 nM
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High CD74 expression (CD74 +++) | ||
| Method Description |
CD74 Milatuzumab DANAPAE152C S375C-P1-L18-P2 was tested in EOL-1
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| In Vitro Model | Chronic eosinophilic leukemia | EoL-1 cells | CVCL_0258 | ||