Linker Information
General Information of This Linker
| Linker ID |
LIN0YGIEZ
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| Linker Name |
Linker of ADC1-4
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C38H54N8O14
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CCC(NC2[C@H](O)[C@H](O)[C@@H](C(O)=O)O2)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(CO)C=C3)=O)=O)C
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| InChI |
InChI=1S/C38H54N8O14/c1-20(2)29(35(56)43-23(7-6-17-40-38(39)59)33(54)41-22-11-9-21(19-47)10-12-22)45-34(55)24(13-14-26(49)44-36-31(53)30(52)32(60-36)37(57)58)42-25(48)8-4-3-5-18-46-27(50)15-16-28(46)51/h9-12,15-16,20,23-24,29-32,36,47,52-53H,3-8,13-14,17-19H2,1-2H3,(H,41,54)(H,42,48)(H,43,56)(H,44,49)(H,45,55)(H,57,58)(H3,39,40,59)/t23-,24-,29-,30-,31+,32-,36?/m0/s1
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| InChIKey |
LLVRYKUFPFLNLL-OCTJVUJGSA-N
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| Pharmaceutical Properties |
Molecule Weight
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846.892
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Polar area
|
345.22
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Complexity
|
1660.695341
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xlogp Value
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-2.4106
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Heavy Count
|
60
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Rot Bonds
|
24
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Hbond acc
|
13
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Hbond Donor
|
11
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Each Antibody-drug Conjugate Related to This Linker