Linker Information
General Information of This Linker
| Linker ID |
LIN0XXFFX
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| Linker Name |
CN119630431A-ADC-42-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C61H93N5O24S2
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCCCC[C@H](NC(CCOCCOCCN1C(C(SC2=CC=CC=C2)=C(SC3=CC=CC=C3)C1=O)=O)=O)C(NCC(N[C@H](C(O)=O)CC(O)=O)=O)=O)=O
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| InChI |
InChI=1S/C61H93N5O24S2/c1-77-22-23-81-28-29-83-32-33-85-36-37-87-40-41-89-44-45-90-43-42-88-39-38-86-35-34-84-31-30-82-27-25-78-19-15-52(67)62-17-9-8-14-50(58(72)63-47-54(69)65-51(61(75)76)46-55(70)71)64-53(68)16-20-79-24-26-80-21-18-66-59(73)56(91-48-10-4-2-5-11-48)57(60(66)74)92-49-12-6-3-7-13-49/h2-7,10-13,50-51H,8-9,14-47H2,1H3,(H,62,67)(H,63,72)(H,64,68)(H,65,69)(H,70,71)(H,75,76)/t50-,51-/m0/s1
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| InChIKey |
GAYNQIHZOMZHIR-TZTPEXNXSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1344.56
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Polar area
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357.6
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Complexity
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2208.601003
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xlogp Value
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1.7254
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Heavy Count
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92
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Rot Bonds
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62
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Hbond acc
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24
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 31 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.037 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||