Linker Information
General Information of This Linker
| Linker ID |
LIN0XVJBZ
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| Linker Name |
WO2023156321A1-B1-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C30H44N8O9S
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| Isosmiles |
C[C@H](NC([C@@H](NC(COCCNS(NC(OC[C@@H]1[C@]2([H])CCC(N=NN3)=C3CC[C@@]21[H])=O)(=O)=O)=O)C(C)C)=O)C(NC4=CC=C(CO)C=C4)=O
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| InChI |
InChI=1S/C30H44N8O9S/c1-17(2)27(29(42)32-18(3)28(41)33-20-6-4-19(14-39)5-7-20)34-26(40)16-46-13-12-31-48(44,45)37-30(43)47-15-23-21-8-10-24-25(36-38-35-24)11-9-22(21)23/h4-7,17-18,21-23,27,31,39H,8-16H2,1-3H3,(H,32,42)(H,33,41)(H,34,40)(H,37,43)(H,35,36,38)/t18-,21-,22+,23-,27-/m0/s1
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| InChIKey |
JNXJROLCCGMGCC-WISOBGQLSA-N
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| Pharmaceutical Properties |
Molecule Weight
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692.796
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Polar area
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242.83
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Complexity
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1435.942061
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xlogp Value
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-0.1006
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Heavy Count
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48
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Rot Bonds
|
16
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Hbond acc
|
11
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker