Linker Information
General Information of This Linker
| Linker ID |
LIN0XQVAO
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| Linker Name |
WO2024140449A1+ADC3+Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C19H30N4O8
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| Isosmiles |
O=C(N1CCOCCOCCC(NCC(N[C@@H](CCCCN)C(O)=O)=O)=O)C=CC1=O
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| InChI |
InChI=1S/C19H30N4O8/c20-7-2-1-3-14(19(28)29)22-16(25)13-21-15(24)6-9-30-11-12-31-10-8-23-17(26)4-5-18(23)27/h4-5,14H,1-3,6-13,20H2,(H,21,24)(H,22,25)(H,28,29)/t14-/m0/s1
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| InChIKey |
XWCRGFGKOPFCMI-AWEZNQCLSA-N
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| Pharmaceutical Properties |
Molecule Weight
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442.469
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Polar area
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177.36
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Complexity
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608.4237513
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xlogp Value
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-1.8507
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Heavy Count
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31
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Rot Bonds
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17
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Hbond acc
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8
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
wO2024140449A1 ADC3 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5-50 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||
wO2024140449A1 ADC4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5-50 nM
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|||
| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||