Linker Information
General Information of This Linker
| Linker ID |
LIN0XKRXK
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| Linker Name |
US20230285580A1 B12-B2 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C32H48N8O10S
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| Isosmiles |
C[C@H](NC([C@@H](NC(COCCOCCNS(NC(OC[C@@H]1[C@]2([H])CCC(N=NN3)=C3CC[C@@]21[H])=O)(=O)=O)=O)C(C)C)=O)C(NC4=CC=C(CO)C=C4)=O
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| InChI |
InChI=1S/C32H48N8O10S/c1-19(2)29(31(44)34-20(3)30(43)35-22-6-4-21(16-41)5-7-22)36-28(42)18-49-15-14-48-13-12-33-51(46,47)39-32(45)50-17-25-23-8-10-26-27(38-40-37-26)11-9-24(23)25/h4-7,19-20,23-25,29,33,41H,8-18H2,1-3H3,(H,34,44)(H,35,43)(H,36,42)(H,39,45)(H,37,38,40)/t20-,23-,24+,25-,29-/m0/s1
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| InChIKey |
FLLMBLWPWHDESO-HHXKHJODSA-N
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| Pharmaceutical Properties |
Molecule Weight
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736.849
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Polar area
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252.06
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Complexity
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1485.699108
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xlogp Value
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-0.084
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Heavy Count
|
51
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Rot Bonds
|
19
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Hbond acc
|
12
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker