Linker Information
General Information of This Linker
| Linker ID |
LIN0XKFDP
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| Linker Name |
Aminobenzazepine-linker Formula II-2
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C58H105F4NO26
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| Isosmiles |
CNCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(OC1=C(F)C(F)=CC(F)=C1F)=O
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| InChI |
InChI=1S/C58H105F4NO26/c1-63-3-5-66-7-9-68-11-13-70-15-17-72-19-21-74-23-25-76-27-29-78-31-33-80-35-37-82-39-41-84-43-45-86-47-49-88-51-50-87-48-46-85-44-42-83-40-38-81-36-34-79-32-30-77-28-26-75-24-22-73-20-18-71-16-14-69-12-10-67-8-6-65-4-2-55(64)89-58-56(61)53(59)52-54(60)57(58)62/h52,63H,2-51H2,1H3
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| InChIKey |
DNHQBCHKMSLEBA-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1308.451
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Polar area
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259.85
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Complexity
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1485.595216
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xlogp Value
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2.1563
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Heavy Count
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89
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Rot Bonds
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76
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Hbond acc
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27
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Hbond Donor
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1
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||