Linker Information
General Information of This Linker
| Linker ID |
LIN0XEDUP
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| Linker Name |
DBCO-4,4nnAA-PEG-VKG
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C66H102N6O20
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| Isosmiles |
O=C(N(C1)CC1(C2)CC2C(NCCC(N3CC4=C(C#CC5=C3C=CC=C5)C=CC=C4)=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(O)=O)=O)=O
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| InChI |
InChI=1S/C66H102N6O20/c1-52(2)62(64(77)69-57(65(78)79)12-7-8-19-67)70-59(73)17-21-80-23-25-82-27-29-84-31-33-86-35-37-88-39-41-90-43-45-92-46-44-91-42-40-89-38-36-87-34-32-85-30-28-83-26-24-81-22-18-60(74)71-50-66(51-71)47-56(48-66)63(76)68-20-16-61(75)72-49-55-11-4-3-9-53(55)14-15-54-10-5-6-13-58(54)72/h3-6,9-11,13,52,56-57,62H,7-8,12,16-51,67H2,1-2H3,(H,68,76)(H,69,77)(H,70,73)(H,78,79)/t57-,62-/m0/s1
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| InChIKey |
OPPBSHRTMORALX-CRKRVGFWSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1299.564
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Polar area
|
311.23
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Complexity
|
2386.481272
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xlogp Value
|
2.5131
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Heavy Count
|
92
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Rot Bonds
|
55
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Hbond acc
|
20
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker