Linker Information
General Information of This Linker
| Linker ID |
LIN0XDTNZ
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|---|---|---|---|---|---|---|
| Linker Name |
DBCO-4.4 nAA-B-Glucuronide-PEG12
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C74H106N6O26
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(NC[C@H](NC(C1CC2(CN(C2)C(CCCCC(N3C4=C(C#CC5=C(C=CC=C5)C3)C=CC=C4)=O)=O)C1)=O)C(NCCC(NCC6=CC(CO)=CC=C6O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O7)=O)=O)=O
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| InChI |
InChI=1S/C74H106N6O26/c1-93-22-23-95-26-27-97-30-31-99-34-35-101-38-39-103-42-43-104-41-40-102-37-36-100-33-32-98-29-28-96-25-24-94-21-19-63(83)77-48-59(71(90)75-20-18-62(82)76-47-57-44-53(50-81)14-17-61(57)105-73-68(88)66(86)67(87)69(106-73)72(91)92)78-70(89)58-45-74(46-58)51-79(52-74)64(84)12-6-7-13-65(85)80-49-56-10-3-2-8-54(56)15-16-55-9-4-5-11-60(55)80/h2-5,8-11,14,17,44,58-59,66-69,73,81,86-88H,6-7,12-13,18-43,45-52H2,1H3,(H,75,90)(H,76,82)(H,77,83)(H,78,89)(H,91,92)/t59-,66-,67-,68+,69-,73+/m0/s1
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| InChIKey |
TVSBWNFUFSILRC-VQZOOMCYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1495.678
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Polar area
|
404.46
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Complexity
|
3099.575589
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xlogp Value
|
0.1381
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Heavy Count
|
106
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Rot Bonds
|
55
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Hbond acc
|
25
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker