Linker Information
General Information of This Linker
| Linker ID |
LIN0XCDTD
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|---|---|---|---|---|---|---|
| Linker Name |
L6-P1 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C69H113N13O27
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCN(N=N1)C=C1CN(C(C2=CC(NC([C@@H](NC([C@@H](NC(CCOCCN3C(C=CC3=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=CC=C2COC(O)=O)=O)CC4=CN(N=N4)CCOCCOCCOCCOCCOCCOCCOCCOC
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| InChI |
InChI=1S/C69H113N13O27/c1-54(2)64(74-61(83)11-16-94-19-15-82-62(84)9-10-63(82)85)66(87)73-60(6-5-12-71-68(70)89)65(86)72-56-8-7-55(53-109-69(90)91)59(48-56)67(88)79(49-57-51-80(77-75-57)13-17-95-24-26-99-32-34-103-40-42-107-46-44-105-38-36-101-30-28-97-22-20-92-3)50-58-52-81(78-76-58)14-18-96-25-27-100-33-35-104-41-43-108-47-45-106-39-37-102-31-29-98-23-21-93-4/h7-10,48,51-52,54,60,64H,5-6,11-47,49-50,53H2,1-4H3,(H,72,86)(H,73,87)(H,74,83)(H,90,91)(H3,70,71,89)/t60-,64-/m0/s1
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| InChIKey |
APYWLQKTJJVCPH-YWIZBNOOSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1556.727
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Polar area
|
464.97
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Complexity
|
2774.697535
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xlogp Value
|
-0.2237
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Heavy Count
|
109
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Rot Bonds
|
71
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Hbond acc
|
32
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Hbond Donor
|
6
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Each Antibody-drug Conjugate Related to This Linker