Linker Information
General Information of This Linker
| Linker ID |
LIN0XAAGZ
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| Linker Name |
DBCO-6.6nnAA-B-Glucuronide-PEG1
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C56H70N6O15
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| Isosmiles |
COCCC(NC[C@@H](C(NCCC(NCC1=CC(CO)=CC=C1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C(O)=O)O)O)O)=O)=O)NC(C3CCC4(CCN(CC4)C(CCCCC(N5C6=C(C=CC=C6)C#CC7=C(C5)C=CC=C7)=O)=O)CC3)=O)=O
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| InChI |
InChI=1S/C56H70N6O15/c1-75-29-21-45(65)59-32-41(53(72)57-26-20-44(64)58-31-40-30-35(34-63)14-17-43(40)76-55-50(70)48(68)49(69)51(77-55)54(73)74)60-52(71)38-18-22-56(23-19-38)24-27-61(28-25-56)46(66)12-6-7-13-47(67)62-33-39-10-3-2-8-36(39)15-16-37-9-4-5-11-42(37)62/h2-5,8-11,14,17,30,38,41,48-51,55,63,68-70H,6-7,12-13,18-29,31-34H2,1H3,(H,57,72)(H,58,64)(H,59,65)(H,60,71)(H,73,74)/t41-,48-,49-,50+,51-,55+/m0/s1
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| InChIKey |
IOBKIWQKCDDKLD-QNJLNQKBSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1067.203
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Polar area
|
302.93
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Complexity
|
2571.290473
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xlogp Value
|
1.5159
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Heavy Count
|
77
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Rot Bonds
|
22
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Hbond acc
|
14
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker