Linker Information
General Information of This Linker
| Linker ID |
LIN0WYOQZ
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| Linker Name |
CN119326907A Trastuzumab-GDP-D-P1/P1-P1-GGFG-Dxd Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C63H89N17O24
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| Isosmiles |
O=C(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)CNC(CCOCC(N=N2)=CN2CCOCCN(C(CCOCCN(N=N3)C=C3COCCC(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)CCNC(CCC(NC[C@H]5[C@@H](O)[C@@H](O)[C@H](O)[C@H](O5)O)=O)=O)=O
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| InChI |
InChI=1S/C63H89N17O24/c81-47(11-12-48(82)65-29-46-58(94)59(95)60(96)63(99)104-46)64-16-17-78(18-24-101-26-20-80-37-43(75-77-80)39-103-22-14-50(84)67-31-52(86)69-33-54(88)73-45(62(98)71-35-57(92)93)28-41-9-5-2-6-10-41)55(89)15-23-100-25-19-79-36-42(74-76-79)38-102-21-13-49(83)66-30-51(85)68-32-53(87)72-44(61(97)70-34-56(90)91)27-40-7-3-1-4-8-40/h1-10,36-37,44-46,58-60,63,94-96,99H,11-35,38-39H2,(H,64,81)(H,65,82)(H,66,83)(H,67,84)(H,68,85)(H,69,86)(H,70,97)(H,71,98)(H,72,87)(H,73,88)(H,90,91)(H,92,93)/t44-,45-,46-,58+,59+,60-,63-/m0/s1
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| InChIKey |
ZBBZUGXZDBARKD-RLAQNCLVSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1468.5
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Polar area
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574.4
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Complexity
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3281.920103
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xlogp Value
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-8.231
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Heavy Count
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104
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Rot Bonds
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50
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Hbond acc
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28
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Hbond Donor
|
16
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Each Antibody-drug Conjugate Related to This Linker