Linker Information
General Information of This Linker
| Linker ID |
LIN0WWTYB
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| Linker Name |
TW202506738A-C-182-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C44H52N10O12
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| Isosmiles |
C[C@H](NC(CCCNC(CN(N(C(CN1C(C=CC1=O)=O)=O)CC(NCCCC(N[C@H](C(NC(C=C2)=CC=C2C)=O)C)=O)=O)C(CN3C(C=CC3=O)=O)=O)=O)=O)C(NC(C=C4)=CC=C4C)=O
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| InChI |
InChI=1S/C44H52N10O12/c1-27-9-13-31(14-10-27)49-43(65)29(3)47-33(55)7-5-21-45-35(57)23-53(41(63)25-51-37(59)17-18-38(51)60)54(42(64)26-52-39(61)19-20-40(52)62)24-36(58)46-22-6-8-34(56)48-30(4)44(66)50-32-15-11-28(2)12-16-32/h9-20,29-30H,5-8,21-26H2,1-4H3,(H,45,57)(H,46,58)(H,47,55)(H,48,56)(H,49,65)(H,50,66)/t29-,30-/m0/s1
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| InChIKey |
MWFOXCDELAPDOD-KYJUHHDHSA-N
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| Pharmaceutical Properties |
Molecule Weight
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912.958
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Polar area
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289.98
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Complexity
|
2016.014767
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xlogp Value
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-0.89496
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Heavy Count
|
66
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Rot Bonds
|
22
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Hbond acc
|
12
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Hbond Donor
|
6
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Each Antibody-drug Conjugate Related to This Linker