Linker Information
General Information of This Linker
| Linker ID |
LIN0WVZBG
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
ADC-5 BGB-C-277 Linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C21H33N5O7S2
|
|||||
| Isosmiles |
CC(C)[C@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(N[C@H](C(O)=O)CCCNC(N)=O)=O.[S].[S]
|
|||||
| PubChem CID | ||||||
| InChI |
InChI=1S/C21H33N5O7.2S/c1-13(2)18(19(30)24-14(20(31)32)7-6-11-23-21(22)33)25-15(27)8-4-3-5-12-26-16(28)9-10-17(26)29;;/h9-10,13-14,18H,3-8,11-12H2,1-2H3,(H,24,30)(H,25,27)(H,31,32)(H3,22,23,33);;/t14-,18-;;/m0../s1
|
|||||
| InChIKey |
ZZKXYGQTPYRXTF-MPWAUAJRSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
531.657
|
Polar area
|
188
|
||
|
Complexity
|
720
|
xlogp Value
|
0.9269
|
|||
|
Heavy Count
|
35
|
Rot Bonds
|
15
|
|||
|
Hbond acc
|
6
|
Hbond Donor
|
5
|
|||
Each Antibody-drug Conjugate Related to This Linker