Linker Information
General Information of This Linker
| Linker ID |
LIN0WTVRL
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|---|---|---|---|---|---|---|
| Linker Name |
AU2023279443A1, Example A13, Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C34H44N8O12
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| Isosmiles |
O=C(NCC(NCC(N[C@H](C(NCC(NCO)=O)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CCCCCN2C(C=CC2=O)=O)=O)CC(N[C@@H](CCO3)C3=O)=O
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| InChI |
InChI=1S/C34H44N8O12/c43-20-38-28(47)18-37-32(51)23(15-21-7-3-1-4-8-21)41-29(48)19-35-27(46)17-36-33(52)24(16-26(45)39-22-12-14-54-34(22)53)40-25(44)9-5-2-6-13-42-30(49)10-11-31(42)50/h1,3-4,7-8,10-11,22-24,43H,2,5-6,9,12-20H2,(H,35,46)(H,36,52)(H,37,51)(H,38,47)(H,39,45)(H,40,44)(H,41,48)/t22-,23-,24-/m0/s1
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| InChIKey |
GAGVIZZOHZGDQL-HJOGWXRNSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
756.77
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Polar area
|
287.61
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Complexity
|
1512.894545
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xlogp Value
|
-4.0795
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Heavy Count
|
54
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Rot Bonds
|
22
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Hbond acc
|
12
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker