Linker Information
General Information of This Linker
| Linker ID |
LIN0WRAFS
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
Anti-Her2-AL1- LP12 linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C39H58N8O18
|
|||||
| Isosmiles |
NCCOCCOCCOCCN(N=N1)C2=C1CC(OCC(NCCNC(C3=CC(COC(NCC(NCC(O)=O)=O)=O)=CC=C3O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](O4)C(O)=O)=O)=O)CCCC2
|
|||||
| InChI |
InChI=1S/C39H58N8O18/c40-7-11-59-13-15-61-16-14-60-12-10-47-27-4-2-1-3-24(18-26(27)45-46-47)62-22-30(49)41-8-9-42-36(55)25-17-23(21-63-39(58)44-19-29(48)43-20-31(50)51)5-6-28(25)64-38-34(54)32(52)33(53)35(65-38)37(56)57/h5-6,17,24,32-35,38,52-54H,1-4,7-16,18-22,40H2,(H,41,49)(H,42,55)(H,43,48)(H,44,58)(H,50,51)(H,56,57)/t24?,32-,33-,34+,35-,38+/m0/s1
|
|||||
| InChIKey |
VMCCBIFUJIZNMA-FGGUVUGYSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
926.931
|
Polar area
|
373.03
|
||
|
Complexity
|
1782.99003
|
xlogp Value
|
-3.8151
|
|||
|
Heavy Count
|
65
|
Rot Bonds
|
27
|
|||
|
Hbond acc
|
20
|
Hbond Donor
|
10
|
|||
Each Antibody-drug Conjugate Related to This Linker