Linker Information
General Information of This Linker
| Linker ID |
LIN0WQVMZ
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| Linker Name |
Dis linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C3H6O2S
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| Isosmiles |
O=C(O)CCS
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| PubChem CID | ||||||
| InChI |
InChI=1S/C3H6O2S/c4-3(5)1-2-6/h6H,1-2H2,(H,4,5)
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| InChIKey |
DKIDEFUBRARXTE-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
106.146
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Polar area
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37.3
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Complexity
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44
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xlogp Value
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0.3909
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Heavy Count
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6
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Rot Bonds
|
2
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Hbond acc
|
2
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Hbond Donor
|
2
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
EDB-L19-diS-DM1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
237 ng/mL
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Negative EDB expression (EDB-) | ||
| Method Description |
Calculated using four-parameter logistic model #203 with XLfit v4.2 (IDBS)
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| In Vitro Model | Colon cancer | HT29 cells | CVCL_A8EZ | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
268 ng/mL
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Positive EDB expression (EDB+++/++) | ||
| Method Description |
Calculated using four-parameter logistic model #203 with XLfit v4.2 (IDBS)
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| In Vitro Model | Normal | WI38-VA13 cells | CVCL_2759 | ||
EDB-diS-L19-4574 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
429 ng/mL
|
Negative EDB expression (EDB-) | ||
| Method Description |
Calculated using four-parameter logistic model #203 with XLfit v4.8 (IDBS)
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| In Vitro Model | Colon cancer | HT29 cells | CVCL_A8EZ | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
487 ng/mL
|
Positive EDB expression (EDB+++/++) | ||
| Method Description |
Calculated using four-parameter logistic model #203 with XLfit v4.7 (IDBS)
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| In Vitro Model | Normal | WI38-VA13 cells | CVCL_2759 | ||