Linker Information
General Information of This Linker
| Linker ID |
LIN0VXTGJ
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| Linker Name |
CN119326907A Trastuzumab-GDP-D-P1/P2-C2-GGFG-Dxd Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C65H93N17O23
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| Isosmiles |
O=C(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)CNC(CCCC(N=N2)=CN2CCOCCN(CCNC(CCC(NC[C@H]3[C@@H](O)[C@@H](O)[C@H](O)[C@H](O3)O)=O)=O)C(CCOCCOCCN(N=N4)C=C4CCCC(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C65H93N17O23/c83-49(68-34-53(87)70-36-55(89)74-46(63(99)72-38-58(92)93)31-42-9-3-1-4-10-42)15-7-13-44-40-81(78-76-44)23-27-103-26-22-80(21-20-66-51(85)17-18-52(86)67-33-48-60(96)61(97)62(98)65(101)105-48)57(91)19-25-102-29-30-104-28-24-82-41-45(77-79-82)14-8-16-50(84)69-35-54(88)71-37-56(90)75-47(64(100)73-39-59(94)95)32-43-11-5-2-6-12-43/h1-6,9-12,40-41,46-48,60-62,65,96-98,101H,7-8,13-39H2,(H,66,85)(H,67,86)(H,68,83)(H,69,84)(H,70,87)(H,71,88)(H,72,99)(H,73,100)(H,74,89)(H,75,90)(H,92,93)(H,94,95)/t46-,47-,48-,60+,61+,62-,65-/m0/s1
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| InChIKey |
DNGPREXLXMWKLI-YXOCHNBESA-N
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| Pharmaceutical Properties |
Molecule Weight
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1480.555
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Polar area
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565.17
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Complexity
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3300.371487
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xlogp Value
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-7.3824
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Heavy Count
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105
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Rot Bonds
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51
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Hbond acc
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27
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Hbond Donor
|
16
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Each Antibody-drug Conjugate Related to This Linker