Linker Information
General Information of This Linker
| Linker ID |
LIN0VWICE
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|---|---|---|---|---|---|---|
| Linker Name |
Drug linker PB008
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C42H68N8O18
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CN1C(C=CC1=O)=O)=O)CCCCN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(C=C2)CO)=O)=O)C
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| InChI |
InChI=1S/C42H68N8O18/c1-22(2)34(41(67)47-26(7-5-14-44-42(43)68)39(65)45-24-10-8-23(19-51)9-11-24)48-40(66)25(46-31(58)18-50-32(59)12-13-33(50)60)6-3-4-15-49(16-27(54)35(61)37(63)29(56)20-52)17-28(55)36(62)38(64)30(57)21-53/h8-13,22,25-30,34-38,51-57,61-64H,3-7,14-21H2,1-2H3,(H,45,65)(H,46,58)(H,47,67)(H,48,66)(H3,43,44,68)/t25-,26-,27-,28-,29+,30+,34-,35+,36+,37+,38+/m0/s1
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| InChIKey |
KPBANVJPDDBVNO-JZIYHXFWSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
973.044
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Polar area
|
434.67
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Complexity
|
1689.300442
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xlogp Value
|
-7.0546
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Heavy Count
|
68
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Rot Bonds
|
32
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Hbond acc
|
19
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Hbond Donor
|
17
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Each Antibody-drug Conjugate Related to This Linker