Linker Information
General Information of This Linker
| Linker ID |
LIN0VUSTQ
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|---|---|---|---|---|---|---|
| Linker Name |
Conjugate No.167 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C54H54N12O10
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| Isosmiles |
CN1C(C(N(C=C2)C3=C2C=C(OC)C=C3)=O)=CC(C4=CC=C(NC(C5=NC(NC(CCCOC(C=C(N[C@@H](OCC(N=N6)=CN6CCCN(C7=O)C(C=C7)=O)[C@@]8([H])N9CC(C8)=C)C(C9=O)=C%10)=C%10OC)=O)=CN5C)=O)C=C4)=C1
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| InChI |
InChI=1S/C54H54N12O10/c1-32-22-42-52(76-31-37-29-63(60-59-37)18-7-19-65-48(68)15-16-49(65)69)56-40-26-45(44(74-5)25-39(40)53(71)66(42)27-32)75-21-6-8-47(67)57-46-30-62(3)50(58-46)51(70)55-36-11-9-33(10-12-36)35-24-43(61(2)28-35)54(72)64-20-17-34-23-38(73-4)13-14-41(34)64/h9-17,20,23-26,28-30,42,52,56H,1,6-8,18-19,21-22,27,31H2,2-5H3,(H,55,70)(H,57,67)/t42-,52-/m0/s1
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| InChIKey |
IOBLNURVMZUFOO-DEDCKFBCSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1031.1
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Polar area
|
240.3
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Complexity
|
3369.947997
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xlogp Value
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5.7817
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Heavy Count
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76
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Rot Bonds
|
19
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Hbond acc
|
18
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Hbond Donor
|
3
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Each Antibody-drug Conjugate Related to This Linker