Linker Information
General Information of This Linker
| Linker ID |
LIN0VTYZK
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| Linker Name |
CN119326907A Trastuzumab-GDP-D-P1/P2-P1-GGFG-Dxd Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C65H93N17O25
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| Isosmiles |
O=C(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)CCOCC2=CN(N=N2)CCOCCN(CCNC(CCC(NC[C@H](O3)[C@@H](O)[C@@H](O)[C@H](O)[C@H]3O)=O)=O)C(CCOCCOCCN(N=N4)C=C4COCCC(NCC(NCC(N[C@@H](CC5=CC=CC=C5)C(NCC(O)=O)=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C65H93N17O25/c83-49(11-12-50(84)67-31-48-60(96)61(97)62(98)65(101)107-48)66-16-17-80(18-24-103-25-19-81-38-44(76-78-81)40-105-21-13-51(85)68-32-53(87)70-34-55(89)74-46(63(99)72-36-58(92)93)29-42-7-3-1-4-8-42)57(91)15-23-102-27-28-104-26-20-82-39-45(77-79-82)41-106-22-14-52(86)69-33-54(88)71-35-56(90)75-47(64(100)73-37-59(94)95)30-43-9-5-2-6-10-43/h1-10,38-39,46-48,60-62,65,96-98,101H,11-37,40-41H2,(H,66,83)(H,67,84)(H,68,85)(H,69,86)(H,70,87)(H,71,88)(H,72,99)(H,73,100)(H,74,89)(H,75,90)(H,92,93)(H,94,95)/t46-,47-,48-,60+,61+,62-,65-/m0/s1
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| InChIKey |
WUBSWCOQCRFNJB-YXOCHNBESA-N
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| Pharmaceutical Properties |
Molecule Weight
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1512.553
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Polar area
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583.63
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Complexity
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3337.313409
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xlogp Value
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-8.2144
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Heavy Count
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107
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Rot Bonds
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53
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Hbond acc
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29
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Hbond Donor
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16
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Each Antibody-drug Conjugate Related to This Linker